So as the technological world is advancing, so is the world of medicine. After that pandemic era, it was a really difficult to find cures for everything. According to available information, DARPA is looking for the most cutting-edge ways to treat unusual ailments. The company is working on making a drug that will be able to protect you from the cold. The drug has a wide range of applications, including treating hypothermia patients to help them adapt better to the Arctic, and the main concern is generating soldiers who can fight cold conditions through this.
The funds for this drug are sponsored by the Faculty Award Program, which provides a huge amount of support to bring the latest ideas to reality. One of these grants was awarded to faculty members of Rice University and bioengineer Jerzy Szablowski this week.
The money won by Szablowski and his team will be used to find a cure to enhance the ability of your immune system to deal with adaptation to a cold environment by the process of thermogenesis in the human body, most familiar with shivering. The researchers are focusing on the burning of adipose tissue (BAT), or brown fat, to keep your body warm. According to reports, Szablowski’s will collaborate with Miao-Hsueh Chen, a BAT expert and associate professor of pediatric nutrition at Baylor College of Medicine.
According to Szablowski, “the other type of thermogenesis involves BAT, which can generate heat through a chemical process,” according to a statement made about the experiment by Rice University. Non-shivering thermogenesis begins more quickly, but because it is less effective, it is unable to produce as much heat, at least not in humans.
It is hoped that Szablowski’s team will discover a secure method to increase this BAT response’s potency. This might reduce the weeks-long adjustment period that humans typically need to become used to a new cold environment to hours, or it could aid emergency personnel in stabilizing hypothermia sufferers more effectively. The knowledge gained from this research’s findings may also be useful in other contexts. Researchers from other institutions have proposed that altering our BAT response may increase our capacity to burn calories, which, in turn, may improve our ability to treat metabolic disorders like obesity. Additionally, to find substances that may influence BAT regulation, the researchers will employ a novel screening technique, which they claim could enhance our search for additional chemicals that may have similar effects as other drugs in the future.
The primary originality of this screening method, according to Szablowski, is that it is mechanism-agnostic, which means that devising mitigation methods might not require a thorough understanding of the disease or physiological process. In a nutshell, it would enable us to screen a huge variety of medications.
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